Migraines, irritable bowel syndrome, fibormyalgia, obesity and even ADHD can all be traced back to depleted serotonin levels – and the effects on your body can be as damaging as they are diverse. When most people think of serotonin deficiency, the first thing they usually think about is depression. If that someone is you, you’d be right. But there’s a lot more to this neurotransmitter than meets the eye – a lot more.

Serotonin is one of your body’s most crucial chemical messengers. It – along with other neurotransmitters such as dopamine, norepinephrine and epinephrine – control how information is sent in the brain and throughout the body. If levels are low, or if there is a significant imbalance between the various neurotransmitters, any number of symptoms may result, including migraines, depression, anxiety, fibromyalgia, insomnia, obesity, addiction, obsessive thoughts, compulsive behaviors and ADD/ADHD

Research and Examples

Research has made these remarkable discoveries possible. It also provides a novel approach to address some of our most complex modern disorders. For instance, studies show that low levels of serotonin have been linked to binge eating, carbohydrate cravings and weight gain. It’s now wonder then that research has also shown that those that are obese and overweight have levels of serotonin that are well below normal – and clinical trials have shown that increasing brain serotonin levels leads to both reduced caloric intake and weight loss. But low levels of serotonin don’t effect just your waistline.

Studies have also shown that serotonin plays a crucial role in the ability to fall and stay asleep, reduce/eliminate migraines and tension headaches and reduce the pain associated with fibromyalgia. In fact, research shows that increasing serotonin levels can relieve migraines as effectively as standard drug therapies. Once more, the use of amino acids over time can often eliminate migraines once and for all.

An even more surprising connection shows that serotonin is a major player in gut motility, which can be important for disorders ranging from IBS and constipation to inflammatory bowel diseases like Crohn’s disease and Ulcerative colitis. This occurs because special serotonin-releasing cells are found throughout the gastrointestinal (GI) tract. These cells are responsible for stimulating peristaltic motion, which are the rhythmic contractions that help move waste though the GI tract. If these cells don’t function properly, peristalsis slows or becomes erratic, which can lead to symptoms.

Proper serotonin (and neurotransmitter) function is essential for your health. Research has shown that supplementing with 5-hydroxytryptophan (5-HTP) along with other key amino acids and cofactors can help restore proper serotonin levels naturally and effectively – this is called amino acid therapy. This can provide relief from a whole host of symptoms, including depression, anxiety, migraines, insomnia,and fibromyalgia (to name a few:)).

 

References

  1. Gendall KA, Joyce PR. Meal–induced changes in tryptophan:LNAA ratio: effects on craving and binge eating. Eat Behav. 2000 Sep;1(1):53–62.
  2. Breum L, Rasmussen MH, Hilsted J, Fernstrom JD. Twenty–four–hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction. Am J Clin Nutr. 2003 May;77(5):1112–1118.
  3. Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5–hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm 1989;76(2):109–117.
  4. Cangiano C, Ceci F, Cascino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5–hydroxytryptophan. Am J Clin Nutr 1992 Nov;56(5):863–867.
  5. Riemann D, Vorderholzer U. Treatment of depression and sleep disorders. Significance of serotonin and L–tryptophan in pathophysiology and therapy. Fortschr Med. 1998 Nov;116(32):40–42.
  6. Titus F, Dávalos A, Alom J, Codina A. 5–Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol. 1986;25(5):327–329.
  7. Ribeiro CA. L–5–Hydroxytryptophan in the prophylaxis of chronic tension–type headache: a double–blind, randomized, placebo–controlled study. For the Portuguese Head Society. Headache. 2000 Jun;40(6):451–456.
  8. Birdsall TC. 5–Hydroxytryptophan: a clinically–effective serotonin precursor. Altern Med Rev. 1998 Aug;3(4):271–280.
  9. Hrycaj P, Stratz T, Muller W. Platelet 3Himipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol. 1993;20:1986–1988. [letter]
  10. Russell IJ, Michalek JE, Vipraio GA, et al. Platelet 3H–imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol 1992;19:104–109.
  11. Fayyaz M, Lackner JM. Serotonin receptor modulators in the treatment of irritable bowel syndrome. Ther Clin Risk Manag. 2008 Feb;4(1):41–48.
  12. Gershon MD. The enteric nervous system: a second brain. Hosp Pract (Minneap). 1999 Jul 15;34(7):31–32,35–38,41–42.
  13. Grider JR. Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5–HT4 agonist tegaserod. Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G319–G327.
  14. Poldinger W, Calanchini B, Schwarz W. A functional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5–hydroxytryptophan and fluvoxamine. Psychopathology. 1991;24:53–81.
  15. Kahn RS, Westenberg HG. L–5–hydroxytryptophan in the treatment of anxiety disorders. J Affect Disord. 1985 Mar–Apr;8(2):197–200.
  16. Puttini PS, Caruso I. Primary fibromyalgia and 5–hydroxy–L–tryptophan: a 90 day open study. J Int Med Res. 1992;20:182–189.